CULT: Article on Variation in Gene Expression
- Subject: CULT: Article on Variation in Gene Expression
- From: "Steve Szabo" s*@erols.com
- Date: Mon, 30 Sep 2002 23:24:54 -0400
- Importance: Normal
Someone who has access to Nature may want to take a look at this, and any
application it may have to those who are working with iris to develop a
strain.
http://www.nature.com/nglink/v32/n2/abs/ng983.html
Published online: 3 September 2002, doi:10.1038/ng983
volume 32 no. 2 pp 261 - 266
Variation in gene expression within and among natural populations
Marjorie F. Oleksiak1, Gary A. Churchill2 & Douglas
L. Crawford1
Evolution may depend more strongly on variation in gene
expression than on differences between variant forms of proteins1. Regions
of DNA that affect gene expression are highly variable, containing 0.6%
polymorphic sites2. These naturally occurring polymorphic nucleotides can
alter in vivo transcription rates3-7. Thus, one might expect substantial
variation in gene expression between individuals. But the natural variation
in mRNA expression for a large number of genes has not been measured. Here
we report microarray studies addressing the variation in gene expression
within and between natural populations of teleost fish of the genus
Fundulus. We observed statistically significant differences in expression
between individuals within the same population for approximately 18% of 907
genes. Expression typically differed by a factor of 1.5, and often more than
2.0. Differences between populations increased the variation. Much of the
variation between populations was a positive function of the variation
within populations and thus is most parsimoniously described as random. Some
genes showed unexpected patterns of expression—changes unrelated to
evolutionary distance. These data suggest that substantial natural variation
exists in gene expression and that this quantitative variation is important
in evolution.
\\Steve//
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