Re: genetic ramblings
Before anyone else tries this you might want to note the MSDS (Material
Safety Data Sheets) on Colchicine. I've pasted it in below.
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COLCHICINE
MSDS Number: C5038 --- Effective Date: 12/08/96
--------------------------------------------------------------------------------
1. Product Identification
Synonyms: Acetamide,
N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo [a]
heptelen-7-yl) -, (S)-
CAS No.: 64-86-8
Molecular Weight: 399.44
Chemical Formula: C22H25NO6
Product Codes: 2323
--------------------------------------------------------------------------------
2. Composition/Information on Ingredients
Ingredient CAS No Percent
Hazardous
--------------------------------------- ------------ -------
---------
Colchicine 64-86-8 90 - 100%
Yes
--------------------------------------------------------------------------------
3. Hazards Identification
Emergency Overview
--------------------------
DANGER! MAY BE FATAL IF SWALLOWED, INHALED OR ABSORBED THROUGH SKIN.
CAUSES SEVERE EYE IRRITATION. CAUSES IRRITATION TO SKIN AND RESPIRATORY
TRACT. POSSIBLE BIRTH DEFECT HAZARD. MAY CAUSE BIRTH DEFECTS BASED ON
ANIMAL DATA. MAY AFFECT THE REPRODUCTIVE SYSTEM.
Potential Health Effects
----------------------------------
Inhalation:
Inhalation may cause irritation to the upper respiratory tract.
Symptoms may include coughing, shortness of breath and chest pain. Other
symptoms may parallel those from ingestion.
Ingestion:
Highly toxic. Death has resulted from single oral doses of 3 to 13 mg.
Acute effects include delayed appearance of nausea, burning in throat,
vomiting, intense diarrhea, abdominal pain, delirium, hypotension,
hypertension, convulsions, and respiratory failure or coma progressing
to cardiovascular collapse, shock and death. Estimated lethal dose is 20
- 65 mg.
Skin Contact:
Causes skin irritation. May be absorbed through skin with symptoms
paralleling ingestion.
Eye Contact:
Causes severe irritation with some threat of absorption into the body.
Chronic Exposure:
A suspect teratogen: can cause birth defects. May affect reproductive
system. Chronic exposure can cause blood effects, skin rash, and
tingling in the extremities.
Aggravation of Pre-existing Conditions:
No information found.
--------------------------------------------------------------------------------
4. First Aid Measures
This material is extremely hazardous. Get medical attention immediately
following overexposure.
Inhalation:
Remove to fresh air. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. Get medical attention immediately.
Monitor for systemic effects.
Ingestion:
Induce vomiting immediately as directed by medical personnel. Never
give anything by mouth to an unconscious person. Get medical attention
immediately. Monitor for systemic effects.
Skin Contact:
Immediately flush skin with plenty of soap and water for at least 15
minutes while removing contaminated clothing and shoes. Get medical
attention, immediately. Wash clothing before reuse. Thoroughly clean
shoes before reuse. Monitor for systemic effects.
Eye Contact:
Immediately flush eyes with plenty of water for at least 15 minutes,
lifting lower and upper eyelids occasionally. Get medical attention
immediately.
Note to Physician:
There is no known effective antidote for this material. If swallowed,
give activated charcoal to absorb any remaining material in the stomach.
Atropine and morphine may be appropriate for relief from abdominal pain.
--------------------------------------------------------------------------------
5. Fire Fighting Measures
Fire:
As with most organic solids, fire is possible at elevated temperatures
or by contact with an ignition source.
Explosion:
Fine dust dispersed in air in sufficient concentrations, and in the
presence of an ignition source is a potential dust explosion hazard.
Fire Extinguishing Media:
Water spray, dry chemical, alcohol foam, or carbon dioxide.
Special Information:
In the event of a fire, wear full protective clothing and
NIOSH-approved self-contained breathing apparatus with full facepiece
operated in the pressure demand or other positive pressure mode.
--------------------------------------------------------------------------------
6. Accidental Release Measures
Remove all sources of ignition. Ventilate area of leak or spill. Keep
unnecessary and unprotected people away from area of spill. Wear
appropriate personal protective equipment as specified in Section 8.
Spills: Pick up and place in a suitable container for reclamation or
disposal, using a method that does not generate dust.
--------------------------------------------------------------------------------
7. Handling and Storage
Keep in a tightly closed container, stored in a cool, dry, ventilated
area. Protect against physical damage. Containers of this material may
be hazardous when empty since they retain product residues (dust,
solids); observe all warnings and precautions listed for the product.
--------------------------------------------------------------------------------
8. Exposure Controls/Personal Protection
Airborne Exposure Limits:
None established.
Ventilation System:
A system of local and/or general exhaust is recommended to keep
employee exposures as low as possible. Local exhaust ventilation is
generally preferred because it can control the emissions of the
contaminant at its source, preventing dispersion of it into the general
work area. Please refer to the ACGIH document, Industrial Ventilation, A
Manual of Recommended Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved):
If the exposure limit is exceeded, wear a supplied air, full-facepiece
respirator, airlined hood, or full-facepiece self-contained breathing
apparatus.
Skin Protection:
Wear impervious protective clothing, including boots, gloves, lab coat,
apron or coveralls, as appropriate, to prevent skin contact.
Eye Protection:
Use chemical safety goggles and/or full face shield where dusting or
splashing of solutions is possible. Maintain eye wash fountain and
quick-drench facilities in work area.
--------------------------------------------------------------------------------
9. Physical and Chemical Properties
Appearance:
Pale yellow powder.
Odor:
Odorless.
Solubility:
Slightly soluble in water.
Specific Gravity:
No information found.
pH:
5.9 (0.5% soln.)
% Volatiles by volume @ 21C (70F):
0
Boiling Point:
No information found.
Melting Point:
142 - 150C (288 - 302F)
Vapor Density (Air=1):
No information found.
Vapor Pressure (mm Hg):
No information found.
Evaporation Rate (BuAc=1):
No information found.
--------------------------------------------------------------------------------
10. Stability and Reactivity
Stability:
Stable under ordinary conditions of use and storage. Becomes darker in
color on exposure to light.
Hazardous Decomposition Products:
Burning may produce carbon monoxide, carbon dioxide, nitrogen oxides.
Hazardous Polymerization:
Will not occur.
Incompatibilities:
Strong oxidizers.
Conditions to Avoid:
Light, incompatibles.
--------------------------------------------------------------------------------
11. Toxicological Information
Toxicological Data:
Oral mouse LD50: 5886 ug/kg. Investigated as a mutagen, reproductive
effector.
Reproductive Toxicity:
In laboratory animals, this compound has caused both birth defects and
damage to the reproductive system.
--------\Cancer
Lists\------------------------------------------------------
---NTP Carcinogen---
Ingredient Known Anticipated IARC
Category
------------------------------------ ----- -----------
-------------
Colchicine (64-86-8) No No
None
--------------------------------------------------------------------------------
12. Ecological Information
Environmental Fate:
No information found.
Environmental Toxicity:
No information found.
--------------------------------------------------------------------------------
13. Disposal Considerations
Whatever cannot be saved for recovery or recycling should be managed in
an appropriate and approved waste disposal facility. Processing, use or
contamination of this product may change the waste management options.
State and local disposal regulations may differ from federal disposal
regulations. Dispose of container and unused contents in accordance with
federal, state and local requirements.
--------------------------------------------------------------------------------
14. Transport Information
Domestic (Land, D.O.T.)
-----------------------
Proper Shipping Name: ALKALOID, SOLID, N.O.S. (COLCHICINE)
Hazard Class: 6.1
UN/NA: UN1544
Packing Group: II
Information reported for product/size: 1G
International (Water, I.M.O.)
-----------------------------
Proper Shipping Name: ALKALOID, SOLID, N.O.S. (COLCHICINE)
Hazard Class: 6.1
UN/NA: UN1544
Packing Group: II
Information reported for product/size: 1G
--------------------------------------------------------------------------------
15. Regulatory Information
--------\Chemical Inventory Status - Part
1\---------------------------------
Ingredient TSCA EC Japan
Australia
----------------------------------------------- ---- --- -----
---------
Colchicine (64-86-8) Yes Yes No
Yes
--------\Chemical Inventory Status - Part
2\---------------------------------
--Canada--
Ingredient Korea DSL NDSL
Phil.
----------------------------------------------- ----- --- ----
-----
Colchicine (64-86-8) No Yes No
Yes
--------\Federal, State & International Regulations - Part
1\----------------
-SARA 302- ------SARA
313------
Ingredient RQ TPQ List
Chemical Catg.
----------------------------------------- --- ----- ----
--------------
Colchicine (64-86-8) 10 10* No
No
--------\Federal, State & International Regulations - Part
2\----------------
-RCRA-
-TSCA-
Ingredient CERCLA 261.33 8(d)
----------------------------------------- ------ ------
------
Colchicine (64-86-8) 1 No No
Chemical Weapons Convention: No TSCA 12(b): No CDTA: No
SARA 311/312: Acute: Yes Chronic: Yes Fire: No Pressure: No
Reactivity: No (Pure / Solid)
Prop 65:
THIS PRODUCT CONTAINS A CHEMICAL(S) KNOWN TO THE STATE OF CALIFORNIA TO
CAUSE BIRTH DEFECTS OR OTHER REPRODUCTIVE HARM.
Australian Hazchem Code: 2X
Poison Schedule: S4
WHMIS:
This MSDS has been prepared according to the hazard criteria of the
Controlled Products Regulations (CPR) and the MSDS contains all of the
information required by the CPR.
--------------------------------------------------------------------------------
16. Other Information
NFPA Ratings: Health: 4 Flammability: 1 Reactivity: 0
Label Hazard Warning:
DANGER! MAY BE FATAL IF SWALLOWED, INHALED OR ABSORBED THROUGH SKIN.
CAUSES SEVERE EYE IRRITATION. CAUSES IRRITATION TO SKIN AND RESPIRATORY
TRACT. POSSIBLE BIRTH DEFECT HAZARD. MAY CAUSE BIRTH DEFECTS BASED ON
ANIMAL DATA. MAY AFFECT THE REPRODUCTIVE SYSTEM.
Label Precautions:
Do not breathe dust. Do not get in eyes, on skin, or on clothing. Keep
container closed. Use only with adequate ventilation. Wash thoroughly
after handling.
Label First Aid:
If swallowed, induce vomiting immediately as directed by medical
personnel. Never give anything by mouth to an unconscious person. If
inhaled, remove to fresh air. If not breathing, give artificial
respiration. If breathing is difficult, give oxygen. In case of contact,
immediately flush eyes or skin with plenty of water for at least 15
minutes while removing contaminated clothing and shoes. Wash clothing
before reuse. In all cases get medical attention immediately.
Product Use:
Laboratory Reagent.
Revision Information:
Pure. New 16 section MSDS format, all sections have been revised.
Disclaimer:
*****************************************************************************************
>>> res@colfax.com 03/15/02 12:43PM >>>
Mike, I've said for a long time that I see an upper limit in the 1500
lb
range. If you want to get past it the good growers are going have to
start
including colchicine treatments. With it I get 300 lbs from 150 lb
seed.
You need to treat the seeds in solution for 48-60 hrs for maximum
results.
What I do is posted in the archives, I think. With my method you can
still
carry on the breeding programs. You only change the pheotypic
displays. I
think you'll get an easy 50% wt increase.
Roger
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